SCAFFOLD collected, reviewed and analyzed relevant quantitative and qualitative information and data on current strategies, methods and tools for workers protection against manufactured nanomaterials (MNMs), in order to identify needs and gaps for proper risk management. Four main topics were analyzed: Risk prevention (MNMs safe design, safe design of manufacturing processes, etc), Risk assessment (occupational exposure and toxicology, measurement equipment and procedures, exposure limit values, etc), Risk protection and control (filtration, PPEs, etc) and finally Risk management (safety management models, tools, implementation level, work procedures, “good practices”, risk communication, etc).