MAINA-NOCK
THEODOSIA


Research Director, Radiopharmacist

MAINA-NOCK THEODOSIA

Present position: Research Director, Molecular Radiopharmacy, INRASTES, NCSR «Demokritos».

Previous Studies and Experience:

  • 1995 – now: Researcher at NCSR «Demokritos» (NCSRD).
  • 1992 – 1994: Visiting Scholar, Pharmacy Department, University of Padova, Italy
  • 1992 : Visiting Scholar, Department of Nuclear Medicine, Ferrara University, Italy
  • 1990-1991: Postdoc at the Institute of Nuclear Medicine, Basel University Hospital, Switzerland
  • 1989-1990: Postdoc at the Department of Chemistry, University of Cincinnati, Cincinnati/OH, USA
  • 1984-1989: PhD in Pharmaceutical Chemistry, Pharmacy School, University of Athens, Athens, Greece
  • 1983-1985: Specialization in Radiopharmacy, Postgraduate School of I/R-RP, NCSRD, Athens, Greece
  • 1982-1983: Research fellow of the National Institution of Research at the Department of Inorganic Chemistry, University of Patras, Patras, Greece
  • 1978-1982: Diploma in Pharmacy, Pharmacy School, University of Patras, Patras, Greece

Research Activities:

In her present position and for more than 25 years now, Dr. Maina-Nock has been guiding research activities aiming at the development and evaluation of a wide spectrum of radiolabeled peptides for application in targeted diagnostic imaging and radionuclide therapy – “theranostics” – of human tumors.

She has been actively involved in the implementation of national and European scientific projects and research networks related to novel peptide radiopharmaceuticals. She has been responsible for MS and PhD candidates completing their Thesis on related topics.

In addition to drawing public funds for research she has pursued connection with local and European industry and clinical partners. As a result, a solid number of peer-reviewed articles, book chapters (>150) and congress presentations (>300) have been publicly released, while distinct products of this research have been evaluated in well reputed European clinical centers.

In 2013, she and her team in collaboration with Erasmus MC received the prestigious “Marie Curie Award” (https://www.eanm.org/congresses-events/awards-grants/winners/) for their work on the “in situ” stabilization of radiopeptides in vivo by means of co-administration of key-protease inhibitors.

Link to Scopus:  https://www.scopus.com/authid/detail.uri?authorId=6701857597#top

Patents:

https://worldwide.espacenet.com/searchResults?submitted=true&locale=en_EP&DB=EPODOC&ST=advanced&TI=&AB=&PN=&AP=&PR=&PD=&PA=&IN=nock+maina&CPC=&IC=

Selected Publications

Selected Grants

Radiolabeled Vectors in Nuclear Oncology

2018-2023 | Cyclotron Rotterdam BV

The research project “Radiolabeled Vectors in Nuclear Oncology” coded Ε12224 with a 5-year duration (2018-2023) is coordinated by Dr. T. Maina-Nock. It concerns a research cooperation of the Molecular Radiopharmacy team with Cyclotron Rotterdam BV, Erasmus, MC, Rotterdam, The Netherlands. The latter...

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New SST2R-antagonists in the diagnosis of neuroendocrine tumors with PET/CT

2020-2022 | ICPO Academy

The research project “New SST2R-antagonists in the diagnosis of neuroendocrine tumors with PET/CT” coded Ε12452 with a 1-year duration (2020-2022) is coordinated by Dr. T. Maina-Nock. It concerns a research cooperation of the Molecular Radiopharmacy team with the Department of Chemistry, ...

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Development of Radiometalated GRPR-Antagonists for Tumor Diagnosis and Therapy

2014-2016 | Advanced Accelerator Applications

The research project “Development of Radiometalated GRPR-Antagonists for Tumor Diagnosis and Therapy” coded Ε11902 with a 3-year duration (2014-2016) is coordinated by Dr. T. Maina-Nock. It concerns a research cooperation of the Molecular Radiopharmacy team with the Nuclear Medicine & Radiology ...

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Improved Tumor Targeting with Radiolabeled Peptidomimetics

2018-2022 | Ludwig Boltzmann Institute Applied Diagnostics/Austrian Science Foundation (FWF)

The research project “Improved Tumor Targeting with Radiolabeled Peptidomimetics” with a 5-year duration (2018-2023) is coordinated by Dr. B. A. Nock. It concerns a research cooperation of the Molecular Radiopharmacy team with the Ludwig Boltzmann Institute Applied Diagnostics, sponsored by Austrian...

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Phase I clinical trial using a novel CCK-2/gastrin receptor-localizing radiolabelled peptide probe for personalized diagnosis and therapy of patients with progressive or metastatic medullary thyroid carcinoma

2013-2016 | ΕΣΠΑ-ERANET

The research project “Phase I clinical trial using a novel CCK-2/gastrin receptor-localizing radiolabelled peptide probe for personalized diagnosis and therapy of patients with progressive or metastatic medullary thyroid carcinoma” coded ERANET TRANSCAN-GRAN-T-MTC (Ε11820) with a 3-year duration (20...

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(Radio)diagnostic - (Radio)therapeutic Peptides and Peptide-like Molecules for Use in Oncology

2007-2014 | EMC, Rotterdam/Biosynthema Lt MO/USA

The research project “(Radio)diagnostic - (Radio)therapeutic Peptides and Peptide-like Molecules for Use in Oncology” coded Ε11461 with a 7-year duration (2007-2014) is coordinated by B. A. Nock. It concerns a research cooperation of the Molecular Radiopharmacy team with the Department of Nuclear Me...

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