KONSTANTOPOULOU
IRENE


Principal Researcher, Biologist

KONSTANTOPOULOU IRENE

Irene Konstantopoulou (F) is currently a Principal Researcher at the Molecular Diagnostics Laboratory (MDL) of NCSR “Demokritos” since 2017. She graduated from the Aristotelian University of Thessaloniki Department of Biology (BSc, 1990) and received her PhD in Molecular Biology & Genetics at the Aristotle University of Thessaloniki (1997), where she studied the genetics and evolution of the heat shock protective mechanisms of various species of the Drosophila fruit flies. Αs a postgraduate student she received funding from the National Scholarship Foundation (IKY, 1992-1995), as well as an Erasmus scholarship (1994) for training in advanced molecular biology techniques in the University of Umeå, Sweden.  She then pursued post-doctoral research on Cancer Genetics and Hereditary Cancer Syndromes at the MDL of NCSR “Demokritos” (1998-2004), where she was recruited as a staff scientist in 2007 and a Faculty member in 2017. She has gained long-standing experience in the Cancer Genetics field since 1998, as well as international recognition. She has been involved in numerous national and international research projects, has supervised more than 20 student theses and internships, and has more than 80 publications in international peer-reviewed PubMed indexed journals, as well as over 200 presentations in national and international conferences. She also participates very actively in several large international consortia, exploring genetic and other interactions that contribute to cancer predisposition. She is a European Board-certified Clinical Laboratory Geneticist since 2017.

Selected Publications

Fountzilas, E., Konstantopoulou, I., Vagena, A., Apostolou, P., Papadimitriou, C., Christodoulou, C., Tryfonopoulos, D., Manousou, K., Delimitsou, A., Papamentzelopoulou, M., Fountzilas, G., Yannoukakos, D. and Fostira, F., Pathology of BRCA1- and BRCA2-associated Breast Cancers: Known and Less Known Connections Clinical Breast Cancer, Volume 20, Pages: 152-159, 2020 [doi]
Fostira, F. and Konstantopoulou, I., Variant Interpretation in Patients with Metastatic Breast Cancer JAMA Oncology, Volume 6, Pages: 581-582, 2020 [doi]
Fachal, L., Aschard, H., Beesley, J., Barnes, D.R., Allen, J., Kar, S., Pooley, K.A., Dennis, J., Michailidou, K., Turman, C., Soucy, P., Lemaçon, A., Lush, M., Tyrer, J.P., Ghoussaini, M., Marjaneh, M.M., Jiang, X., Agata, S., Aittomäki, K., Alonso, M.R., Andrulis, I.L., Anton-Culver, H., Antonenkova, N.N., Arason, A., Arndt, V., Aronson, K.J., Arun, B.K., Auber, B., Auer, P.L., Azzollini, J., Balmaña, J., Barkardottir, R.B., Barrowdale, D., Beeghly-Fadiel, A., Benitez, J., Bermisheva, M., Białkowska, K., Blanco, A.M., Blomqvist, C., Blot, W., Bogdanova, N.V., Bojesen, S.E., Bolla, M.K., Bonanni, B., Borg, A., Bosse, K., Brauch, H., Brenner, H., Briceno, I., Brock, I.W., Brooks-Wilson, A., Brüning, T., Burwinkel, B., Buys, S.S., Cai, Q., Caldés, T., Caligo, M.A., Camp, N.J., Campbell, I., Canzian, F., Carroll, J.S., Carter, B.D., Castelao, J.E., Chiquette, J., Christiansen, H., Chung, W.K., Claes, K.B.M., Clarke, C.L., Mari, V., Berthet, P., Castera, L., Vaur, D., Lallaoui, H., Bignon, Y.-J., Uhrhammer, N., Bonadona, V., Lasset, C., Révillion, F., Vennin, P., Muller, D., Gomes, D.M., Ingster, O., Coupier, I., Pujol, P., Collonge-Rame, M.-A., Mortemousque, I., Bera, O., Rose, M., Baurand, A., Bertolone, G., Faivre, L., Dreyfus, H., Leroux, D., Venat-Bouvet, L., Bézieau, S., Delnatte, C., Chiesa, J., Gilbert-Dussardier, B., Gesta, P., Prieur, F.P., Bronner, M., Sokolowska, J., Coulet, F., Boutry-Kryza, N., Calender, A., Giraud, S., Leone, M., Fert-Ferrer, S., Stoppa-Lyonnet, D., Jiao, Y., Lesueur, F.L., Mebirouk, N., Barouk-Simonet, E., Bubien, V., Longy, M., Sevenet, N., Gladieff, L., Toulas, C., Reimineras, A., Sobol, H., Paillerets, B.B.-D., Cabaret, O., Caron, O., Guillaud-Bataille, M., Rouleau, E., Belotti, M., Buecher, B., Caputo, S., Colas, C., Pauw, A.D., Fourme, E., Gauthier-Villars, M., Golmard, L., Moncoutier, V., Saule, C., Donaldson, A., Murray, A., Brady, A., Brewer, C., Pottinger, C., Miller, C., Gallagher, D., Gregory, H., Cook, J., Eason, J., Adlard, J., Barwell, J., Ong, K.-R., Snape, K., Walker, L., Izatt, L., Side, L., Tischkowitz, M., Rogers, M.T., Porteous, M.E., Ahmed, M., Morrison, P.J., Brennan, P., Eeles, R., Davidson, R., Collée, J.M., Cornelissen, S., Couch, F.J., Cox, A., Cross, S.S., Cybulski, C., Czene, K., Daly, M.B., de la Hoya, M., Devilee, P., Diez, O., Ding, Y.C., Dite, G.S., Domchek, S.M., Dörk, T., dos-Santos-Silva, I., Droit, A., Dubois, S., Dumont, M., Duran, M., Durcan, L., Dwek, M., Eccles, D.M., Engel, C., Eriksson, M., Evans, D.G., Fasching, P.A., Fletcher, O., Floris, G., Flyger, H., Foretova, L., Foulkes, W.D., Friedman, E., Fritschi, L., Frost, D., Gabrielson, M., Gago-Dominguez, M., Gambino, G., Ganz, P.A., Gapstur, S.M., Garber, J., García-Sáenz, J.A., Gaudet, M.M., Georgoulias, V., Giles, G.G., Glendon, G., Godwin, A.K., Goldberg, M.S., Goldgar, D.E., González-Neira, A., Tibiletti, M.G., Greene, M.H., Grip, M., Gronwald, J., Grundy, A., Guénel, P., Hahnen, E., Haiman, C.A., Håkansson, N., Hall, P., Hamann, U., Harrington, P.A., Hartikainen, J.M., Hartman, M., He, W., Healey, C.S., Heemskerk-Gerritsen, B.A.M., Heyworth, J., Hillemanns, P., Hogervorst, F.B.L., Hollestelle, A., Hooning, M.J., Hopper, J.L., Howell, A., Huang, G., Hulick, P.J., Imyanitov, E.N., Sexton, A., Christian, A., Trainer, A., Spigelman, A., Fellows, A., Shelling, A., Fazio, A.D., Blackburn, A., Crook, A., Meiser, B., Patterson, B., Clarke, C., Saunders, C., Hunt, C., Scott, C., Amor, D., Marsh, D., Edkins, E., Salisbury, E., Haan, E., Neidermayr, E., Macrea, F., Farshid, G., Lindeman, G., Trench, G., Mann, G., Giles, G., Gill, G., Thorne, H., Campbell, I., Hickie, I., Winship, I., Flanagan, J., Kollias, J., Visvader, J., Stone, J., Taylor, J., Burke, J., Saunus, J., Forbes, J., Hopper, J., Beesley, J., Kirk, J., French, J., Tucker, K., Wu, K., Phillips, K., Lipton, L., Andrews, L., Lobb, L., Walker, L., Kentwell, M., Spurdle, M., Cummings, M., Gleeson, M., Harris, M., Jenkins, M., Young, M.A., Delatycki, M., Wallis, M., Burgess, M., Price, M., Brown, M., Southey, M., Bogwitz, M., Field, M., Friedlander, M., Gattas, M., Saleh, M., Hayward, N., Pachter, N., Cohen, P., Duijf, P., James, P., Simpson, P., Fong, P., Butow, P., Williams, R., Kefford, R., Scott, R., Milne, R., Balleine, R., Dawson, S.–J., Lok, S., O’Connell, S., Greening, S., Nightingale, S., Edwards, S.L., Fox, S., McLachlan, S.-A., Lakhani, S., Antill, Y., Aalfs, C., Meijers-Heijboer, H., van Engelen, K., Gille, H., Boere, I., Collée, M., van Deurzen, C., Hooning, M., Obdeijn, I.-M., van den Ouweland, A., Seynaeve, C., Siesling, S., Verloop, J., van Asperen, C., Devilee, P., van Cronenburg, T., Blok, R., de Boer, M., Garcia, E.G., Adank, M., Hogervorst, F., Jenner, D., van Leeuwen, F., Rookus, M., Russell, N., Schmidt, M., van den Belt-Dusebout, S., Kets, C., Mensenkamp, A., de Bock, T., van der Hout, A., Mourits, M., Oosterwijk, J., Ausems, M., Koudijs, M., Clarke, C., Marsh, D., Scott, R., Baxter, R., Yip, D., Carpenter, J., Davis, A., Pathmanathan, N., Simpson, P., Graham, D., Sachchithananthan, M., Isaacs, C., Iwasaki, M., Jager, A., Jakimovska, M., Jakubowska, A., James, P.A., Janavicius, R., Jankowitz, R.C., John, E.M., Johnson, N., Jones, M.E., Jukkola-Vuorinen, A., Jung, A., Kaaks, R., Kang, D., Kapoor, P.M., Karlan, B.Y., Keeman, R., Kerin, M.J., Khusnutdinova, E., Kiiski, J.I., Kirk, J., Kitahara, C.M., Ko, Y.-D., Konstantopoulou, I., Kosma, V.-M., Koutros, S., Kubelka-Sabit, K., Kwong, A., Kyriacou, K., Laitman, Y., Lambrechts, D., Lee, E., Leslie, G., Lester, J., Lesueur, F., Lindblom, A., Lo, W.-Y., Long, J., Lophatananon, A., Loud, J.T., Lubiński, J., MacInnis, R.J., Maishman, T., Makalic, E., Mannermaa, A., Manoochehri, M., Manoukian, S., Margolin, S., Martinez, M.E., Matsuo, K., Maurer, T., Mavroudis, D., Mayes, R., McGuffog, L., McLean, C., Mebirouk, N., Meindl, A., Miller, A., Miller, N., Montagna, M., Moreno, F., Muir, K., Mulligan, A.M., Muñoz-Garzon, V.M., Muranen, T.A., Narod, S.A., Nassir, R., Nathanson, K.L., Neuhausen, S.L., Nevanlinna, H., Neven, P., Nielsen, F.C., Nikitina-Zake, L., Norman, A., Offit, K., Olah, E., Olopade, O.I., Olsson, H., Orr, N., Osorio, A., Pankratz, V.S., Papp, J., Park, S.K., Park-Simon, T.-W., Parsons, M.T., Paul, J., Pedersen, I.S., Peissel, B., Peshkin, B., Peterlongo, P., Peto, J., Plaseska-Karanfilska, D., Prajzendanc, K., Prentice, R., Presneau, N., Prokofyeva, D., Pujana, M.A., Pylkäs, K., Radice, P., Ramus, S.J., Rantala, J., Rau-Murthy, R., Rennert, G., Risch, H.A., Robson, M., Romero, A., Rossing, M., Saloustros, E., Sánchez-Herrero, E., Sandler, D.P., Santamariña, M., Saunders, C., Sawyer, E.J., Scheuner, M.T., Schmidt, D.F., Schmutzler, R.K., Schneeweiss, A., Schoemaker, M.J., Schöttker, B., Schürmann, P., Scott, C., Scott, R.J., Senter, L., Seynaeve, C.M., Shah, M., Sharma, P., Shen, C.-Y., Shu, X.-O., Singer, C.F., Slavin, T.P., Smichkoska, S., Southey, M.C., Spinelli, J.J., Spurdle, A.B., Stone, J., Stoppa-Lyonnet, D., Sutter, C., Swerdlow, A.J., Tamimi, R.M., Tan, Y.Y., Tapper, W.J., Taylor, J.A., Teixeira, M.R., Tengström, M., Teo, S.H., Terry, M.B., Teulé, A., Thomassen, M., Thull, D.L., Tischkowitz, M., Toland, A.E., Tollenaar, R.A.E.M., Tomlinson, I., Torres, D., Torres-Mejía, G., Troester, M.A., Truong, T., Tung, N., Tzardi, M., Ulmer, H.-U., Vachon, C.M., van Asperen, C.J., van der Kolk, L.E., van Rensburg, E.J., Vega, A., Viel, A., Vijai, J., Vogel, M.J., Wang, Q., Wappenschmidt, B., Weinberg, C.R., Weitzel, J.N., Wendt, C., Wildiers, H., Winqvist, R., Wolk, A., Wu, A.H., Yannoukakos, D., Zhang, Y., Zheng, W., Hunter, D., Pharoah, P.D.P., Chang-Claude, J., García-Closas, M., Schmidt, M.K., Milne, R.L., Kristensen, V.N., French, J.D., Antoniou, A.C., Chenevix-Trench, G., Simard, J., Easton, D.F., Dunning, A.M., Kraft, P., GEMO Study Collaborators, EMBRACE Collaborators, KConFab Investigators, HEBON Investigators and ABCTB Investigators, Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes Nature Genetics, Volume 52, Pages: 56-73, 2020 [doi]
Papamentzelopoulou, M., Apostolou, P., Fostira, F., Dimitrakakis, C., Loutradis, D., Fountzilas, G., Yannoukakos, D. and Konstantopoulou, I., Prevalence and founder effect of the BRCA1 p.(Val1833Met) variant in the Greek population, with further evidence for pathogenicity and risk modification Cancer Genetics, Volume 237, Pages: 90-96, 2019 [doi]
Shimelis, H., LaDuca, H., Hu, C., Hart, S.N., Na, J., Thomas, A., Akinhanmi, M., Moore, R.M., Brauch, H., Cox, A., Eccles, D.M., Ewart-Toland, A., Fasching, P.A., Fostira, F., Garber, J., Godwin, A.K., Konstantopoulou, I., Nevanlinna, H., Sharma, P., Yannoukakos, D., Yao, S., Feng, B.-J., Davis, B.T., Lilyquist, J., Pesaran, T., Goldgar, D.E., Polley, E.C., Dolinsky, J.S. and Couch, F.J., Triple-negative breast cancer risk genes identified by multigene hereditary cancer panel testing Journal of the National Cancer Institute, Volume 110, Pages: 855-862, 2018 [doi]

Selected Grants

DEcision Support system for Tumor RadIogeNomics of the ovarY

2018-2022 | GSRT

Worldwide, high grade ovarian epithelial cancer (HGOC) remains the most fatal gynecological cancer. In patients with HGOC, the presence of intratumoral genetic heterogeneity is considered an important adverse prognostic factor associated with poor response to treatment and, therefore, poor survival ...

readmore-arrow

Molecular Genetics Analysis of ovarian cancer

2017-2021 | ASTRAZENECA

readmore-arrow

Genetic background investigation of mallignant diseases in children

2020-2021 | ΣΥΛΛΟΓΟΣ ΚΑΡΚΙΝΟΠΑΘΩΝ ΕΘΕΛΟΝΤΩΝ ΦΙΛΩΝ ΙΑΤΡΩΝ (Κ.Ε.Φ.Ι.)

readmore-arrow

Investigation of hereditary predisposition in polyposis and colorectal cancer

2020-2023 | ΕΛΛΗΝΙΚΟ ΙΔΡΥΜΑ ΓΑΣΤΡΕΝΤΕΡΟΛΟΓΙΑΣ ΚΑΙ ΔΙΑΤΡΟΦΗΣ

readmore-arrow

Hellenic Precision Medicine Network on Cancer

2018-2021 | SIEMENS - GSRT

ATTICA MEDICAL PRECISION UNIT 2 Coordinator: National Research Center for Natural Sciences "Demokritos" Partners: National Research Foundation, Alexander Fleming Biomedical Research Center Within the framework of the National Precision Medicine Network, the Precision Medicine Unit at NCSR "...

readmore-arrow
INRASTES - Official Web Site
Skip to content