Identification of genetic biomarkers associated with endometriosis-related infertility and malignant transformation
2018-2020 | Stavros Niarchos Foundation Programme for Industrial Fellowships

Endometriosis is one of the most common gynecological diseases and its prevalence increases to 50% in infertile women. Laparoscopy is the primary surgical choice for the diagnosis and treatment of endometriosis. The main aim of the proposed study is the identification of microRNA biomarkers for non-invasive diagnosis of endometriosis as well as cytogenetic biomarkers for early identification of women with endometriosis who are in danger for malignant transformation. The identification of the above biomarkers for the diagnosis of endometriosis is expected to allow the Genesis Athens Clinic to design new diagnostic services.

Leader: K.N. Manola, Research Director, NCSR “Demokritos”

Postdoctoral Research Fellow on Biodiagnostics: Sophia Zachaki, MSc, PhD.

Company/Co-funder: Genesis Athens Clinic.

Major Achievements

1. Zachaki S, Kouvidi E, Pantou A, Tsarouha H, Mitrakos A, Tounta G, Charalampous I, Manola KN, Kanavakis E, Mavrou A. Low-level X Chromosome Mosaicism: A Common Finding in Women Undergoing IVF. In Vivo. 2020 May-Jun;34(3):1433-1437. doi: 10.21873/invivo.11925.
2. Zachaki S, Kalomoiraki M, Kouvidi E, Promponas M, Syrkos S, Pantou A, Mavrou A, Kanavakis E, Manola K. Cytogenetic findings in ectopic endometrial tissue from infertile women. 12th European Cytogenomics Conference, 6-9 July 2019, Salzburg, Austria. Molecular Cytogenetics, 12 (Suppl 1): 1P63, page 38, 2019.
3. Ζαχάκη Σ, Καλομοιράκη Μ, Κουβίδη Ε, Προμπονάς Ε, Σύρκος Σ, Πάντου Α, Μαύρου Α, Καναβάκης Ε, Μανωλά Κ.Ν. Κυτταρογενετική ανάλυση εκτόπου ενδομητρικού ιστού σε γυναίκες με ενδομητρίωση. 3ο Πανελλήνιο Συνέδριο Αναπαραγωγικής Ιατρικής, 16-18 Οκτωβρίου, Αλεξανδρούπολη.

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