Dr. Dimitrios Mastellos is a Research Director at the National Center for Scientific Research ‘Demokritos’ in Athens, Greece. Dimitrios studied biology at the University of Patras, Greece, and earned his PhD in Immunology from the Medical School of the same institution. His research has been focused on various facets of complement biology and inflammation and on studying their broader implications in health, disease and therapy.

During his postdoctoral training with Professor John Lambris at the School of Medicine of the University of Pennsylvania, he applied animal models to interrogate the role of complement-triggered signaling pathways in diverse pathophysiological processes and immunological milieus. His research at ‘Demokritos’ focuses on how complement modulates innate immune activation, host-pathogen interactions and inflammatory signaling in health and disease.

His group is also involved in developing novel biodiagnostic tools for monitoring complement activity in clinical disorders and assessing drug efficacy in clinical trials that evaluate complement-targeted inhibitors. He has co-authored >80 publications including 3 book chapters on topics of innate immunity, complement pathobiology and host-pathogen interactions (Scopus h-index: 40, citations >7,300, listed in Clarivate’s 2023 Highly Cited Researchers /Web of Science).

He has guest-edited special issues on complement-targeted therapeutics and associated diseases and teaches basic aspects of molecular and cellular immunology, complement pathobiology and therapeutic applications in seven graduate programs of Greek Universities. His research has been funded by the NIH, EU (FP7), the Greek Secretariat of Research and Technology, Empirikion Foundation, ESCMID and other charities.