Knowledge about nanotechnology-enabled processes and products and related nanosafety issues (hazards, fate, risk…) is growing rapidly, achieved through numerous European or national programs launched over the last decade, but effective use of this knowledge for risk management by market actors is lagging behind. The EC4SafeNano initiative tried to bridge the gap between scientific knowledge and the market. It linked the nanosafety scientific community, including expert institutes/organizations active in translational research, with the wider stakeholder community. The EC4SafeNano partnership set up a structure to integrate nanosafety services across the member states and propose them to market actors. It provided an interface between the scientific community and the market actors. EC4SafeNano focused on development of ‘fit-for-purpose’ solutions and provision of access to reliable data and experience to help solve the environment, health and safety challenges that hinder the development of safe and sustainable innovation for nanotechnology. EC4SafeNano aimed to establish principles for safe management of nanotechnology and to assist public and private organizations and industry in the application of these principles.