Dr. Aris Chiotellis is a Researcher (Level C) at the Laboratory of Radiopharmaceutical Chemistry at the Institute of Nuclear and Radiological Sciences, Technology, Energy & Safety, NCSR “Demokritos”. His academic education began with a Chemistry Degree from University of Athens (2003) and a M.Sc. in Medicinal Chemistry from University of Thessaloniki (2005). He then performed his doctoral thesis in Radiopharmaceutical Chemistry at the Medical School of Athens (2007) followed by a postdoctoral position at the Laboratory of Bioorganic Chemistry and Natural Product Synthesis at NCSR “Demokritos” (2007-2008). After completion of his military duties, he spent six years (2010-2016) at the Centre for Radiopharmaceutical Sciences of the Federal Institute of Technology (ETH) in Zurich, Switzerland followed by a Research Fellow position at the School of Medicine of University of Nottingham, UK (2016-2018).
Dr Chiotellis’ research activities focus on the development of PET and SPECT radiotracers for use in oncology and other areas of medical interest. He is especially interested in lead optimization and the 18F labelling of small bioactive molecules and the development of theranostics using match-pair radionuclides. Currently, his research work focuses on the development of 18F-PET radiotracers for imaging the kynurenine pathway aiming to clarify its involvement in tumor progression and immunomodulation. Dr. Chiotellis is also co-lecturing «Radiopharmaceutical Chemistry» at both under-graduate and post-graduate level at the School of Pharmacy of the University of Athens.
This research plan aims at developing an innovative platform of PET and SPECT imaging agents that concomitantly target indoleamine 2,3-dioxygenase 1/2 (IDO1/IDO2) and tryptophan 2,3-dioxygenase (TDO), three enzymes that play a crucial role in tumor biology. In particular, the enhanced tryptophan cat...