Mr. Achilleas Krikas will develop an in-silico trial that will allow the deep analysis of vascular diseases and will be sought to be compared with existing in-vitro and in-vivo experiments so as to assure its validity. The modeling tool will incorporate several computation modules that will be able to simulate and analyze the pathway of the particles. More, specifically, the main focus will lie on the dispersion of particles in blood, the adhesion of particles on endothelium and diffusion of particles within the arterial wall.