STRATIKOS
EFSTRATIOS


Research Director, Chemist

STRATIKOS EFSTRATIOS

2014-present: Research director, National Center for Scientific Research “Demokritos”, Athens, Greece

2015-2017: Visiting Professor, Department of Chemistry, University of Athens, Greece

2009-2014: Senior Researcher, National Center for Scientific Research “Demokritos”, Athens, Greece

2005-2008: Researcher, National Center for Scientific Research “Demokritos”, Athens, Greece

2003-2004: Postdoctoral researcher, Department of Cell Biology, Harvard Medical School, Boston, MA

1999-2003: Postdoctoral researcher, Structural Biology Laboratory, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA

1994-1999: PhD in Biochemistry, Department of Biochemistry and Molecular Biology,University of Illinois at Chicago, Chicago, IL, USA,Advisor: Dr. Peter G.W. Gettins

1989-1994: B.S. Degree in Chemistry, University of Athens, Athens, Greece.

Google Scholar link here. Pubmed link here. Scopus link here

Selected Publications

Mavridis, G., Arya, R., Domnick, A., Zoidakis, J., Makridakis, M., Vlahou, A., Mpakali, A., Lelis, A., Georgiadis, D., Tampé, R., Papakyriakou, A., Stern, L.J. and Stratikos, E., A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by endoplasmic reticulum aminopeptidase 1 Journal of Biological Chemistry, Volume 295, Pages: 7193-7210, 2020 [doi]
Liddle, J., Hutchinson, J.P., Kitchen, S., Rowland, P., Neu, M., Cecconie, T., Holmes, D.S., Jones, E., Korczynska, J., Koumantou, D., Lea, J.D., Nickels, L., Pemberton, M., Phillipou, A., Schneck, J.L., Sheehan, H., Tinworth, C.P., Uings, I., Wojno-Picon, J., Young, R.J. and Stratikos, E., Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation ACS Applied Materials and Interfaces, 2020 [doi]
Koumantou, D., Barnea, E., Martin-Esteban, A., Maben, Z., Papakyriakou, A., Mpakali, A., Kokkala, P., Pratsinis, H., Georgiadis, D., Stern, L.J., Admon, A. and Stratikos, E., Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1) Cancer Immunology, Immunotherapy, Volume 68, Pages: 1245-1261, 2019 [doi]
Giastas, P., Mpakali, A., Papakyriakou, A., Lelis, A., Kokkala, P., Neu, M., Rowland, P., Liddle, J., Georgiadis, D. and Stratikos, E., Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1 Proceedings of the National Academy of Sciences of the United States of America, Volume 116, Pages: 26709-26716, 2019 [doi]
Mpakali, A., Saridakis, E., Harlos, K., Zhao, Y., Kokkala, P., Georgiadis, D., Giastas, P., Papakyriakou, A. and Stratikos, E., Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity Journal of Medicinal Chemistry, Volume 60, Pages: 2963-2972, 2017 [doi]

Selected Grants

Selection of antigenic peptides by aminopeptidases

2013-2016 | Greek Secreteriat for R&T action "Funding retained ERC proposals"

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Modulating neoantigen epitope generation for melanoma immunotherapy

2016-2019 | Harry J. Lloyd Charitable Trust

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New HDL-related therapies for autoimmune and cardiovascular diseases

2020-2022 | Greek Secretariat for R&T, Action “Research-Create-Innovate”

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Structure-based discovery of novel modulators of Insulin-Regulated aminopeptidase

2020-2021 | Ministry of Education

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Marie Skłodowska-Curie Action - Innovative Training Network

2021-2025 | European Commission

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