Despite the growing momentum of renewable fuels, several challenges remain. These include high production costs, infrastructure limitations, regulatory gaps, and market fragmentation. This integrated study aims to provide a comprehensive analysis of the market potential and opportunities for renewable fuels in Greece, identifying key sectors for market development and addressing critical issues and risks. In a nutshell, Greece has recognized the importance of renewable fuels through its National Energy and Climate Plan (NECP) and the National Strategy for Hydrogen and Renewable Gases. The Greek government has set ambitious targets for hydrogen production and use, aiming to leverage the country’s renewable energy potential. Key initiatives include the promotion of hydrogen production from renewable sources, the integration of renewable gases into existing natural gas networks, and the development of regulatory frameworks to support the renewable fuel market.