INRASTES
Education Activities

Education activities per Research Area

INRASTES has long reputation and strong commitment in postgraduate education and training, since the establishment of NCSR “Demokritos” in the 1960’s. Our research groups are involved in various education activities, including the supervision of graduate students, PhD candidates and junior postdocs, and running across the four different research pillars of the institute. In certain cases, postgraduate research projects can cover multiple pillars or be in collaboration with other institutes of “Demokritos”. A list of on-going and recently completed projects can be found below.

If you are interested in conducting your theses or training with us, please visit the corresponding sections:

 

Postgraduate and undergraduate teaching activities

Many of our researchers are invited lecturers in accredited postgraduate programmes organized by Universities in Greece and abroad, the Greek Atomic Energy Commission, and the International Atomic Energy Agency (IAEA). Delivered courses range from Radiation Physics, Nuclear Reactor Safety, Nuclear Analytical Techniques, Industrial Safety, Environment and Solar Energy, to Radiopharmaceuticals, Clinical Chemistry, Molecular Diagnostics and Protein Chemistry.

 

Dissemination actions

Our research and education activities are disseminated to final year Science and Engineering students and graduates during the annual Summer School of NCSR “Demokritos”, in the form of lectures, laboratory demonstrations and tours.
In addition, we participate in the regular visits organized by the Education office of NCSR “Demokritos”, where we welcome several hundred high-school students visiting our laboratories per year. We also deliver lectures and conduct demonstrations addressed to the general public, e.g. during the annual festivities organized under the European Researchers Nights.

 

Video presentation of INRASTES education activities (in Greek):

 

INRASTES Education Officers


Dr Effie Marcoulaki (Energy, Safety and Environmental Technologies; Nuclear Technology)

 

Dr Yiota Petrou (Biodiagnostic Sciences and Technologies; Radiological Sciences and Radiopharmacy)

 

List of on-going and recently completed theses

Theses list

(12 )
Clear All
See More
Triantopoulou Sotiria
SUPERVISOR:

Εvaluation of new quinazolines derivatives as radiosensitisers and anticancer agents in cancer cell lines that over express receptors of the ErbB family

Quinazolines are anticancer agents that are clinically used for the targeted treatment of tumors where the ErbB receptors are overexpressed or bear specific mutations. These agents can also act as radiosensitizers. The purpose of this Ph.D. project is the evaluation of new anticancer quinazolines derivatives as radiosensitizers. These will belong to the following categories:

  1. Derivatives that inhibit the tyrosine kinase domain and have inhibitory action in specific mutations of EGFR: deletions of exon 19 (del 746-750) or/and the exon 21 (L858R) (1st generation)
  2. Derivatives that have broader activity to overcome EGFR resistant mutations to the 1st generation and inhibit all ErbB family signaling (2nd generation).
  3. Derivatives that have high specificity for the T790 mutation of EGFR, which is the most common mechanism of resistance to the therapy using the first two generation quinazolines (3rd generation).

For the purpose of this study, the new produced quinazolines derivatives are evaluated for their anti-cancer activity and for their ability of radiosensitizing. The most promising radiosensitizers of this study will be compared with the current quinazolines that are used nowadays in clinical routine. The ultimate goal is to propose new promising anticancer agents that can also act as radiosensitizers.

See More
Habibi Martha
SUPERVISOR: TERZOUDI GEORGIA

The use of cytogenetic and molecular endpoints as biomarkers of low dose radiation exposure in interventional cardiology

The extensive use of low doses of ionizing radiation (≤100 mSv) for diagnostic and therapeutic purposes increases concern on the radiation safety of both patients and physicians. Ionizing radiation exposures have almost doubled in the last decade, mainly due to the rise in medical diagnostic and therapeutic interventions, which are responsible for approximately 40% of the cumulative effective dose of radiation to the population. Despite the wide use of low-ionizing-radiation doses and the recent evidence that cancer risk may increase even at lower doses (between 50-100 mSv)  the effects of such exposures in patients exposed to cardiac images and interventional cardiology procedures remain unclear.

According to epidemiologic literature, the impact of low doses are hampered by limited statistical power at radiation levels of less than 100 mSv, even for very large studies. Alternatively, the investigation of the radiation-induced effects after exposure to low doses could be carried out with radiobiological data. The present study’s objective is to determine the biological effects of low doses in patients exposed to ionizing radiation during interventional cardiology procedures by using several biomarkers and the correlation of these doses with the potential development of cancer.

The 1st  objective involves the use of molecular and cytogenetic biomarkers to investigate the biological effects delivered to patients after their exposure to cardiovascular procedures at Onassis Cardiac Surgery Centre. Blood samples (6-7 ml) from  patients who undergo ordinary interventional cardiology procedures, such as Coronary Angiography, Percutaneous Transluminal Coronary Angioplasty, and ablation are collected directly before, and immediately after the end of the procedure and incubated in heparin-containing vials for each time interval. The induction and repair of DSBs is visualized and quantified by using the highly sensitive epigenetic biomarker γ-H2AX, a phosphorylated histone H2A variant. Chromosomal aberrations and micronuclei are both crucial predictors of the degree of radiation damage. The frequency of dicentric chromosomes and micronuclei is detected and is compared to the baseline.

Furthermore, the 2nd objective involves the potentiation of the unrepaired DSBs to induce asymmetric cell divisions and chromosomal instability, is tested by using the methodology of CB-iFISH that combines cytokinesis block mediated cell culturing with interphase Fluorescence in situ Hybridization (CB-iFISH) in human lymphocytes that are irradiated in vitro with low ionizing radiation doses. This combined methodology enables the visualization of centromeric regions in the micronuclei as well as the monitoring of the chemically-induced asymmetric cell divisions. The evaluation of the potential ability of the unrepaired radiation-induced DSBs to induce chromosomal instability and asymmetric cell division, will contribute in the research of radiobiology and radioprotection.

See More
Nikolakopoulou Aggeliki
SUPERVISOR: TERZOUDI GEORGIA

Development of cytogenetic assays for the assessment of individual radiosensitivity and evaluation of modern individualized radiotherapy techniques

Radiation Therapy (RT) is often used in conjunction with other therapies such as chemotherapy or tumour removal surgery as an integral part of both curative and palliative treatments for cancer. While RT is one of the most effective single modalities in cancer therapy, it can have significant side effects both during and after treatment, which can impact both the quality and the duration of life. Although rapid technological advances have led to a more precise delivery of radiation dose and to a decreased risk of side effects, there is still a significant need for personalized treatment to be achieved through the development of predictive tools that may guide therapy decisions. Project’s objectives are the prediction of individual radiosensitivity in clinical practice, the investigation of the potential of combining radiation therapy with G2/M cell cycle checkpoint abrogators in vitro, as well as, the evaluation of the efficiency of advanced radiotherapy techniques such as VMAT and IMRT, using phantoms in conjunction with cytogenetic techniques.

See More
Mavragani Ifigeneia
SUPERVISOR: TERZOUDI GEORGIA

Biological consequences of complex DNA damage induced by high-LET ionizing radiations

See More
Karachristou Ioanna
SUPERVISOR: TERZOUDI GEORGIA

Absorbed dose estimation and risk individualization based on ionizing radiation-induced chromosomal aberrations in peripheral blood lymphocytes

See More
Ioannidou Agapi
SUPERVISOR: MANOLA KALLIOPI

Cytogenetic, molecular and epigenetic investigation of Chronic Lymphocytic Leukemia

See More
Kakosaiou Aikaterini
SUPERVISOR: MANOLA KALLIOPI

Cytogenetic, molecular and epigenetic investigation of Acute Myeloid Leukemia

See More
Daraki Aggeliki
SUPERVISOR: MANOLA KALLIOPI

Cytogenetic and molecular analysis of patients with primary and secondary acute myeloid leukemia

See More
Karakosta Maria
SUPERVISOR: MANOLA KALLIOPI

Investigation of Chronic Lymphocytic Leukemia by conventional and molecular cytogenetic methods

See More
Alexoudi Athanasia
SUPERVISOR: SAMBANI CONSTANTINA

Polymorphisms of detoxifying genes in patients with Multiple Sclerosis

See More
Zachaki Sofia-Ourania
SUPERVISOR: SAMBANI CONSTANTINA

Cytogenetic alterations, genetic polymorphisms and methylation of detoxifying genes in the pathogenesis of Myelodysplastic Syndromes

See More
Georgakakos Vasilios
SUPERVISOR: SAMBANI CONSTANTINA

Karyotypic and molecular cytogenetic analysis of Greek patients with childhood Acute Lymphoblastic Leukemia

INRASTES - Official Web Site
Skip to content